The Red Skull has assembled an army of supervillains and other henchmen in a plot to take over the world. Along with battling generic enemies, players also face Klaw, the Living Laser, Whirlwind, a Sentinel , Wizard, the Grim Reaper, the
Mandarin , Juggernaut , Ultron , The Controller , the assassin
Crossbones and finally the Red Skull himself.
Players can choose to play as one of four members of the Avengers: Captain America , Iron Man , Hawkeye , and Vision. Each character can fight hand-to-hand, throw select items when on the ground, and use a ranged special attack, either a projectile weapon (Captain America's shield and Hawkeye's arrows) or an energy beam (Iron Man and Vision), known as that character's "Avenger Attack". During a jump, Captain America and Hawkeye can attack with a flying kick, while Iron Man and Vision instead attack by firing their energy beams at a 45 degree angle. Other Avengers, including the Wasp,
Quicksilver , Wonder Man, and Namor the Sub-Mariner , appear when special power-ups are collected, allowing those characters to temporarily assist the players' characters.